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Cellosaurus CUTO-22 (CVCL_C5VR)

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Cell line name CUTO-22
Synonyms CUTO22; Colorado University Thoracic Oncology 22
Accession CVCL_C5VR
Resource Identification Initiative To cite this cell line use: CUTO-22 (RRID:CVCL_C5VR)
Comments Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:6324; KIF5B + HGNC; HGNC:9967; RET; Name(s)=KIF5B-RET; Note=KIF5B exon 23 fused to RET exon 12 (PubMed=33795352).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=33795352; DOI=10.1124/molpharm.120.000207; PMCID=PMC11033948
Laura Schubert, Anh T. Le, Adriana Estrada-Bernal, Andrea E. Doak, Minjae Yoo, Sarah E. Ferrara, Andrew Goodspeed, Fumi Kinose, Uwe Rix, Aik-Choon Tan, Robert C. Doebele;
Novel human-derived RET fusion NSCLC cell lines have heterogeneous responses to RET inhibitors and differential regulation of downstream signaling.
Mol. Pharmacol. 99:435-447(2021)

Cross-references
Encyclopedic resources Wikidata; Q116048813
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number6