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Cellosaurus LG-2 (CVCL_C5UW)

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Cell line name LG-2
Synonyms LG2; J. Thom; JB; 7W502; Leibold-Gatti-2
Accession CVCL_C5UW
Resource Identification Initiative To cite this cell line use: LG-2 (RRID:CVCL_C5UW)
Comments Population: Caucasian; Scandinavian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Proteomics; HLA class II peptidome.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
HLA typing Source: PubMed=25469497
Class I
HLA-AA*02
HLA-BB*27:05
HLA-CC*01

Source: PubMed=12133989
Class I
HLA-AA*02
HLA-BB*27:05:02
HLA-CC*01
Class II
HLA-DPDPA1*01:01
DPB1*02:01
HLA-DQDQA1*01:01
DQB1*05:01
HLA-DRDRB1*01:01

Source: IPD-IMGT/HLA=10984
Class I
HLA-BB*02:01,27:05
Class II
HLA-DPDPA1*01:03:01:01
HLA-DQDQA1*01:01:01:01
DQB1*05:01:01:01
HLA-DRDRB1*01:01:01:01
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C5VJ (LG2 DO-KO-1)CVCL_C5VK (LG2 DO-KO-2)
Originate from same individual CVCL_E716 ! JESTHOM
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=84414; DOI=10.1111/j.1399-0039.1979.tb01134.x
Richard A. Gatti, Wolfgang Leibold;
HLA-D typing with lymphoblastoid cell lines. IV. Allelic relationships.
Tissue Antigens 13:35-44(1979)

PubMed=6808075; DOI=10.1084/jem.156.2.550; PMCID=PMC2186769
Sanna M. Goyert, John E. Shively, Jack Silver;
Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.
J. Exp. Med. 156:550-566(1982)

PubMed=2824477; DOI=10.1016/S0021-9258(18)47699-5
Joan C. Gorga, Vaclav Horejsi, David R. Johnson, Rajgopal Raghupathy, Jack Leonard Strominger;
Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.
J. Biol. Chem. 262:16087-16094(1987)

PubMed=12133989; DOI=10.4049/jimmunol.169.3.1593
Casper Paludan, Kara Bickham, Sarah Nikiforow, Ming L. Tsang, Kiera Goodman, Willem Albert Hanekom, Jean-Francois Fonteneau, Stefan Stevanovic, Christian Munz;
Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells.
J. Immunol. 169:1593-1603(2002)

PubMed=25469497; DOI=10.1002/art.38980
Alejandro Sanz-Bravo, Jose Campos, Marina S. Mazariegos, Jose Antonio Lopez de Castro;
Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues.
Arthritis Rheumatol. 67:692-701(2015)

PubMed=30573663; DOI=10.1074/mcp.RA118.000956; PMCID=PMC6398211
Padma P. Nanaware, Mollie M. Jurewicz, John D. Leszyk, Scott A. Shaffer, Lawrence J. Stern;
HLA-DO modulates the diversity of the MHC-II self-peptidome.
Mol. Cell. Proteomics 18:490-503(2019)

Cross-references
Cell line databases/resources IPD-IMGT/HLA; 10984
Encyclopedic resources Wikidata; Q116049680
Proteomic databases PRIDE; PXD008500
PRIDE; PXD010301
Entry history
Entry creation15-Dec-2022
Last entry update27-Nov-2025
Version number5