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Cellosaurus H460/TR (CVCL_C5ST)

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Cell line name H460/TR
Accession CVCL_C5ST
Resource Identification Initiative To cite this cell line use: H460/TR (RRID:CVCL_C5ST)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0459 (NCI-H460)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=26498137; DOI=10.3892/ijo.2015.3216
Kyung-Chan Kim, Suk-Hwan Baek, Chuhee Lee;
Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells.
Int. J. Oncol. 47:2296-2303(2015)

Cross-references
Encyclopedic resources Wikidata; Q116049271
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5