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Cellosaurus MCF-7:CFR (CVCL_C5RV)

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Cell line name MCF-7:CFR
Synonyms MCF7:CFR
Accession CVCL_C5RV
Resource Identification Initiative To cite this cell line use: MCF-7:CFR (RRID:CVCL_C5RV)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DC70 (MCF-7.5C)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=32453591; DOI=10.1021/acs.jmedchem.0c00456; PMCID=PMC8258866
Yang-Feng Li, Jiong Zhao, Lauren M. Gutgesell, Zheng-Nan Shen, Kiira Ratia, Katherine Dye, Oleksii Dubrovskyi, Hui-Ping Zhao, Fei Huang, Debra A. Tonetti, Gregory Robert James Thatcher, Rui Xiong;
Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and palbociclib.
J. Med. Chem. 63:7186-7210(2020)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4630713
Encyclopedic resources Wikidata; Q116049774
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number4