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Cellosaurus MCF-7/F (CVCL_C5RU)

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Cell line name MCF-7/F
Accession CVCL_C5RU
Resource Identification Initiative To cite this cell line use: MCF-7/F (RRID:CVCL_C5RU)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=17016657; DOI=10.3892/ijo.29.5.1237
Hong Liu, Dong Cheng, Alyssa K. Weichel, Clodia Osipo, Laura K. Wing, Bin Chen, Teresa E. Louis, Virgil Craig Jordan;
Cooperative effect of gefitinib and fumitremorgin c on cell growth and chemosensitivity in estrogen receptor alpha negative fulvestrant-resistant MCF-7 cells.
Int. J. Oncol. 29:1237-1246(2006)

Cross-references
Encyclopedic resources Wikidata; Q116049772
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number4