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Cellosaurus A549/CDDP (CVCL_C5RT)

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Cell line name A549/CDDP
Synonyms A549/cDDP
Accession CVCL_C5RT
Resource Identification Initiative To cite this cell line use: A549/CDDP (RRID:CVCL_C5RT)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=20716419; DOI=10.3779/j.issn.1009-3419.2009.03.002
Yong-Cheng Pan, Wei-Gang Zhao, Jian-Jun Wang, Quan Liu, Guang-Hai Yang, Jin-Song Li;
Establishment of a multidrug resistance cell line A549/cDDP of human lung adenocarcinoma and expression analysis of multidrug resistance-associated genes.
Zhongguo Fei Ai Za Zhi 12:187-192(2009)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4483129
ChEMBL-Targets; CHEMBL4483225
Encyclopedic resources Wikidata; Q116048462
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number4