Cellosaurus cell line MCF-7/PTX (CVCL

Cellosaurus MCF-7/PTX (CVCL_C5RS)

Cross-references
Cell line name	MCF-7/PTX
Synonyms	MCF7/PTX; MCF-7/P
Accession	CVCL_C5RS
Resource Identification Initiative	To cite this cell line use: MCF-7/PTX (RRID:CVCL_C5RS)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol). Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease	Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0031 (MCF-7)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=24292090; DOI=10.1039/c3mb70428a Si-Ying Chen, Qian Dong, Sa-Sa Hu, Jiang-Xia Cai, Wei-Peng Zhang, Jin-Yao Sun, Tao-Tao Wang, Jiao Xie, Hai-Rong He, Jian-Feng Xing, Jun Lu, Ya-Lin Dong; Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells. Mol. Biosyst. 10:294-303(2014) PubMed=25760096; DOI=10.3892/mmr.2015.3468 Wei-Peng Zhang, Jiang-Xia Cai, Si-Ying Chen, Xiao-Wei Zheng, Sa-Sa Hu, Wei-Hua Dong, Jun Lu, Jian-Feng Xing, Ya-Lin Dong; Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. Mol. Med. Rep. 12:1506-1514(2015)
Chemistry resources	ChEMBL-Cells; CHEMBL4483128 ChEMBL-Targets; CHEMBL4483255
Encyclopedic resources	Wikidata; Q116049773
Entry history
Entry creation	15-Dec-2022
Last entry update	19-Dec-2024
Version number	4