• Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (PubMed=17260012; PubMed=25728708).
  

PubMed=7656272; DOI=10.1007/BF01527402; PMCID=PMC11037630
Alexei F. Kirkin, Troels Reichert Petersen, Anna Catharina Olsen, Li Li, Per thor Straten, Jesper Zeuthen;
Generation of human-melanoma-specific T lymphocyte clones defining novel cytolytic targets with panels of newly established melanoma cell lines.
Cancer Immunol. Immunother. 41:71-81(1995)

PubMed=8968104
Jirina Bartkova, Jiri Lukas, Per Guldberg, Jan Alsner, Alexei F. Kirkin, Jesper Zeuthen, Jiri Bartek;
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
Cancer Res. 56:5475-5483(1996)

PubMed=9288767
Per Guldberg, Per thor Straten, Anette Birck, Vibeke Ahrenkiel, Alexei F. Kirkin, Jesper Zeuthen;
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.
Cancer Res. 57:3660-3663(1997)

PubMed=9688544; DOI=10.1016/S0014-5793(98)00603-6
Karine N. Dzhandzhugazyan, Alexei F. Kirkin, Per thor Straten, Jesper Zeuthen;
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
FEBS Lett. 430:227-230(1998)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Teresa Rodriguez, Rosa Mendez, Chrissy H. Roberts, Francisco Ruiz-Cabello Osuna, I. Anthony Dodi, Miguel Angel Lopez-Nevot, Laura Paco, Isabel Maleno, Steven G.E. Marsh, Graham Pawelec, Federico Garrido;
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Goran Jonsson, Christina Dahl, Johan Staaf, Troy Sandberg, Par-Ola Bendahl, Markus Ringner, Per Guldberg, Ake Borg;
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Christina Dahl, Claus Christensen, Goran Jonsson, Anders Lorentzen, Mette Louise Skjodt, Ake Borg, Graham Pawelec, Per Guldberg;
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=25728708; DOI=10.1111/pcmr.12364
Celia J. Vogel, Marjon A. Smit, Gianluca Maddalo, Patricia Abrao Possik, Rolf W. Sparidans, Sjoerd H. van der Burg, Elizabeth M.E. Verdegaal, Albert J.R. Heck, Ahmed A. Samatar, Jos Heindrik Beijnen, A.F. Maarten Altelaar, Daniel S. Peeper;
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)