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Cellosaurus PA682 PB (CVCL_C539)

[Text version]
Cell line name PA682 PB
Synonyms PA682(PB); PA682PB; Pa682PB; PA682; PA 682; PA-682
Accession CVCL_C539
Resource Identification Initiative To cite this cell line use: PA682 PB (RRID:CVCL_C539)
Comments Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5853; IGL + HGNC; 7553; MYC; Name(s)=MYC-IGL (PubMed=7519050).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Val166Leu (c.496G>C); ClinVar=VCV000639793; Zygosity=Unspecified (PubMed=9787181).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IV25 ! PA682 BM1
CVCL_IV26 ! PA682 PE1
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=6316501; DOI=10.1126/science.6316501
Magrath I.T., Erikson J., Whang-Peng J., Sieverts H., Armstrong G.R., Benjamin D., Triche T.J., Alabaster O., Croce C.M.
Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma.
Science 222:1094-1098(1983)

PubMed=3927261; DOI=10.1093/nar/13.13.4921
Sun L.-H.K., Croce C.M., Showe L.C.
Cloning and sequencing of a rearranged V lambda gene from a Burkitt's lymphoma cell line expressing kappa light chains.
Nucleic Acids Res. 13:4921-4934(1985)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=2470097; DOI=10.1073/pnas.86.9.3257
Shtivelman E., Henglein B., Groitl P., Lipp M., Bishop J.M.
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 86:3257-3260(1989)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=7519050; DOI=10.1002/gcc.2870090408
Zeidler R., Joos S., Delecluse H.-J., Klobeck H.-G., Vuillaume M., Lenoir G.M., Bornkamm G.-W., Lipp M.
Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC.
Genes Chromosomes Cancer 9:282-287(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=9973220
Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G., Magrath I.T., Bhatia K.G.
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Cancer Res. 59:696-703(1999)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=24590883; DOI=10.1002/gcc.22161
Murga Penas E.-M., Schilling G., Behrmann P., Klokow M., Vettorazzi E., Bokemeyer C., Dierlamm J.
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C539
Encyclopedic resources Wikidata; Q54937379
Polymorphism and mutation databases Cosmic; 850212
Cosmic; 931131
Cosmic; 1515190
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number15