Cellosaurus logo
expasy logo

Cellosaurus MSCC-Inv1 (CVCL_C4YL)

[Text version]
Cell line name MSCC-Inv1
Synonyms Inv-1
Accession CVCL_C4YL
Resource Identification Initiative To cite this cell line use: MSCC-Inv1 (RRID:CVCL_C4YL)
Comments Population: Japanese.
Characteristics: Highly invasive clone. Lacks E-cadherin/CDH1 expression due to promoter hypermethylation (PubMed=15328184).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Disease Gingival squamous cell carcinoma (NCIt: C129857)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C4YK (MSCC-1)
Children:
CVCL_C4YN (MSCC-Inv1a)
Sex of cell Male
Age at sampling 49Y
Category Cancer cell line
Publications

PubMed=15328184; DOI=10.1158/1078-0432.CCR-04-0372
Kudo Y., Kitajima S., Ogawa I., Hiraoka M., Sargolzaei S., Keikhaee M.R., Sato S., Miyauchi M., Takata T.
Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin.
Clin. Cancer Res. 10:5455-5463(2004)

PubMed=22207358; DOI=10.4161/epi.7.1.18546; PMCID=PMC3329501
DesRochers T.M., Shamis Y., Alt-Holland A., Kudo Y., Takata T., Wang G.-W., Jackson-Grusby L., Garlick J.A.
The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma.
Epigenetics 7:34-46(2012)

Cross-references
Encyclopedic resources Wikidata; Q116049799
Entry history
Entry creation15-Dec-2022
Last entry update10-Sep-2024
Version number4