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Cellosaurus UM-HACC-2A (CVCL_C4UW)

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Cell line name UM-HACC-2A
Synonyms University of Michigan-Human Adenoid Cystic Carcinoma-2A
Accession CVCL_C4UW
Resource Identification Initiative To cite this cell line use: UM-HACC-2A (RRID:CVCL_C4UW)
Comments Population: Caucasian.
Doubling time: 3.47 days (Note=At 0-4th passages), 2.21 days (Note=At 96-100th passages) (PubMed=30527239).
Derived from site: In situ; Salivary gland, minor salivary gland; UBERON=UBERON_0001830.
Sequence variations
  • Gene fusion; HGNC; HGNC:7545; MYB + HGNC; HGNC:7785; NFIB; Name(s)=MYB-NFIB; Note=MYB exon 5/6 fused to NFIB exon 9 (PubMed=30527239).
Disease Salivary gland adenoid cystic carcinoma (NCIt: C8026)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): PubMed=30527239

Markers:
AmelogeninX
CSF1PO12
D3S135815,17
D5S81811,12
D7S82010
D8S117913
D13S31711,12
D16S5399,11
D18S5118
D21S1130,31.2
FGA20,21
Penta D9,12
Penta E7,12
TH016,7
TPOX10,11
vWA14,18

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Publications

PubMed=30527239; DOI=10.1016/j.oraloncology.2018.10.012; PMCID=PMC6294471
Kristy Anne Warner, Alexandra E. Herzog, Alexander T. Pearson, Zhao-Cheng Zhang, Wei-Shing Wu, Vasu Divi, Christie Rodriguez-Ramirez, Rogerio Moraes Castilho, Peter J. Polverini, Jacques Eduardo Nor;
UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.
Oral Oncol. 87:21-28(2018)

PubMed=38971694; DOI=10.1016/j.oooo.2024.06.005; PMCID=PMC11827064
Kristy Anne Warner, Alexandra E. Herzog, Sosuke Sahara, Felipe Nor, Rogerio Moraes Castilho, Hakan Demirci, Douglas Brian Chepeha, Peter J. Polverini, Jacques Eduardo Nor;
Establishment and characterization of cMYB-expressing human salivary adenoid cystic carcinoma cell lines (UM-HACC-14, UM-HACC-6) and matching patient-derived xenograft model (UM-PDX-HACC-14).
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 138:516-531(2024)

Cross-references
Cell line collections (Providers) ABM; T8326
Encyclopedic resources Wikidata; Q116050707
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number5