Cellosaurus cell line (CVCL

Entry history
Comments	Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: Basophil progenitor cell; CL=CL_0000613.
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line). Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu459Lys (c.1375G>A); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141). Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu462Lys (c.1384G>A); Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=21718141). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Arg (c.395A>G); ClinVar=VCV000376625; Zygosity=Homozygous (from parent cell line).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0379 (Ku812)
Sex of cell	Male
Age at sampling	38Y
Category	Cancer cell line
Entry creation	10-Apr-2025
Last entry update	10-Apr-2025
Version number	1