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Cellosaurus (CVCL_C4S2)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Population: Caucasian.
Doubling time: ~32 hours (PBCF).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; HLA class I peptidome.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=9598804).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (PubMed=9598804; PubMed=17260012; PubMed=23851445; ATCC=HTB-65; DepMap=ACH-000987).
  • Mutation; HGNC; HGNC:3688; FGFR1; Simple; p.Pro252Ser (c.754C>T); Zygosity=Unspecified (PubMed=23851445).
  • Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (ATCC=HTB-65).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*02:01,26:01
HLA-BB*14:02,38:01
HLA-CC*08:02,12:03
Class II
HLA-DPDPB1*04:01,04:02
HLA-DQDQB1*03:01:01,05:01
HLA-DRDRB1*11:01,01:02

Source: PubMed=25960936
Class I
HLA-AA*02:01,26:01

Source: PubMed=26589293
Class I
HLA-AA*02:01,26:01
HLA-BB*14:02,67:02
HLA-CC*12:03,12:03
Class II
HLA-DQDQB1*06:13,06:13
HLA-DRDRB1*11:30,14:17
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.39
Native American1.31
East Asian, North0.6
East Asian, South0.77
South Asian7.24
European, North25.84
European, South61.86
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-65; CLS=300285; Cosmic-CLP=908128; ESTDAB=ESTDAB-050; JCRB=JCRB0066; PubMed=25877200; Technion Genomics Center

Markers:

Run an STR similarity search on this cell line
Web pages Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544466
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-532.html
Publications











Eva Klein, Gertrude Szpingier Henle, Werner Henle, Peter Clifford;
Relation between Epstein-Barr viral and cell membrane immunofluorescence of Burkitt tumor cells. I. Dependence of cell membrane immunofluorescence on presence of EB virus.
J. Exp. Med. 128:1011-1020(1968)




J. Natl. Cancer Inst. 53:751-757(1974)




Proc. Natl. Acad. Sci. U.S.A. 71:4203-4207(1974)



lung and placenta.
J. Natl. Cancer Inst. 56:911-917(1976)



T-lymphoblast cell line.
Proc. Natl. Acad. Sci. U.S.A. 77:593-596(1980)



lines positive and negative for Epstein-Barr virus nuclear antigen. I Physical, cytogenetic, and growth characteristics.
J. Natl. Cancer Inst. 64:465-476(1980)


Philip A. Pizzo, James Gadek, Elaine Sarkin Jaffe, Maria Santaella, Carl Hammer, Michael M. Frank, Gregory Reaman, Ligita Novikovs;
Characterization of lymphoma-derived cell lines: comparison of cell lines positive and negative for Epstein-Barr virus nuclear antigen II. Surface markers.
J. Natl. Cancer Inst. 64:477-483(1980)




J. Exp. Med. 151:1139-1150(1980)


Lawrence W. Anderson, Howard L. Hosick;
Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo.
Cancer Res. 40:1812-1819(1980)


David H. Weinberg, Gary Ketner;
A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.
Proc. Natl. Acad. Sci. U.S.A. 80:5383-5386(1983)


Michael A. O'Donnell, Philip L. Cohen;
Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies.
J. Clin. Invest. 85:86-92(1990)



alveologenic carcinoma.
Mol. Carcinog. 3:387-392(1990)


Frederic G. Barr, David N. Shapiro;
Detection of the t(2;13)(q35;q14) and PAX3-FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization.
Genes Chromosomes Cancer 12:186-192(1995)


Maria Marcela Barrio, Paula Portela, Jose Mordoh;
Functional properties of FC-2.15, a monoclonal antibody that mediates human complement cytotoxicity against breast cancer cells.
Cancer Immunol. Immunother. 41:15-22(1995)



family members.
Cancer Immunol. Immunother. 54:359-371(2005)


Mohammed Kaimul Ahsan, Hiroshi Masutani, Yoshimi Yamaguchi, Yong-Chul Kim, Kisato Nosaka, Masao Matsuoka, Yumiko Nishinaka, Michiyuki Maeda, Junji Yodoi;
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.
Oncogene 25:2181-2191(2006)



studies.
Int. J. Pharm. 334:27-34(2007)



correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Mol. Cancer Res. 5:331-339(2007)




Nat. Biotechnol. 26:1269-1275(2008)




Cancer Immunol. Immunother. 58:1507-1515(2009)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)



aberrant energy metabolic pathway in human cancer.
Cancer Genet. Cytogenet. 196:45-55(2010)




Cancer Genet. Cytogenet. 197:107-116(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson ...Show all 28 authors... , Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)


Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos, Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo;
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Cross-references
Chemistry resources PubChem_Cell_line; CVCL_0445
Encyclopedic resources Wikidata; Q54905336
Polymorphism and mutation databases Progenetix; CVCL_0445
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48