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Cellosaurus SW620-FX-R (CVCL_C4RZ)

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Cell line name SW620-FX-R
Accession CVCL_C4RZ
Resource Identification Initiative To cite this cell line use: SW620-FX-R (RRID:CVCL_C4RZ)
Comments Population: Caucasian.
Characteristics: Resistant to FOLFOXIRI, the combination of 5-FU, folinic acic, oxaliplatin and SN-38.
Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU).
Selected for resistance to: ChEBI; CHEBI_15640; 5-formyltetrahydrofolic acid (Folinic acid; Leucovorin).
Selected for resistance to: ChEBI; CHEBI_31941; Oxaliplatin (Elotaxin; L-OHP).
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0547 (SW620)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=36230735; DOI=10.3390/cancers14194812; PMCID=PMC9564076
George Mourad Ramzy, Laura Boschung, Thibaud Koessler, Celine Delucinge-Vivier, Mylene Docquier, Thomas Alexander McKee, Laura Rubbia-Brandt, Patrycja Nowak-Sliwinska;
FOLFOXIRI resistance induction and characterization in human colorectal cancer cells.
Cancers (Basel) 14:4812.1-4812.17(2022)

Cross-references
Encyclopedic resources Wikidata; Q116050601
Entry history
Entry creation15-Dec-2022
Last entry update10-Apr-2025
Version number6