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Cellosaurus LL1 (CVCL_C4MN)

[Text version]
Cell line name LL1
Synonyms EPB-1; EPB1
Accession CVCL_C4MN
Resource Identification Initiative To cite this cell line use: LL1 (RRID:CVCL_C4MN)
Comments Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized milatuzumab (hLL1; MEDI-115) therapeutic antibody used for the treatment of multiple myeloma, non-Hodgkin's lymphoma and chronic lymphocytic leukemia. When conjugated with doxorubicin, milatuzumab is known as IMMU-110 (hLL1-Dox) and is used for the treatment of relapsed multiple myeloma.
Monoclonal antibody isotype: IgG1, kappa.
Monoclonal antibody target: UniProtKB; P04233; Human CD74.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_2199 (Sp2/0-Ag14)
Category Hybridoma
Publications

PubMed=2663143
Elizabeth J. Pawlak-Byczkowska, Hans J. Hansen, Arnold S. Dion, David M. Goldenberg;
Two new monoclonal antibodies, EPB-1 and EPB-2, reactive with human lymphoma.
Cancer Res. 49:4568-4577(1989)

PubMed=8947500; DOI=10.1042/bj3200293; PMCID=PMC1217930
Hans J. Hansen, Gaik Lin Ong, Habibe Diril, Anita Valdez, Paul A. Roche, Gary L. Griffiths, David M. Goldenberg, Michael Jules Mattes;
Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas.
Biochem. J. 320:293-300(1996)

Cross-references
Biological sample resources ABCD; ABCD_AD421
Encyclopedic resources Wikidata; Q116049709
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2