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Cellosaurus MCF-7(DOX/R) (CVCL_C4M9)

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Cell line name MCF-7(DOX/R)
Synonyms MCF-7 (DOX/R)
Accession CVCL_C4M9
Resource Identification Initiative To cite this cell line use: MCF-7(DOX/R) (RRID:CVCL_C4M9)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=15273662
Inna Chorna, Rostyslav Bilyy, Leonid Datsyuk, Rostyslav Stoika;
Comparative study of human breast carcinoma MCF-7 cells differing in their resistance to doxorubicin: effect of ionizing radiation on apoptosis and TGF-beta production.
Exp. Oncol. 26:111-117(2004)

Cross-references
Encyclopedic resources Wikidata; Q116049775
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number4