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Cellosaurus hTERT-HPNE E6/E7/K-RasG12D/st (CVCL_C470)

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Cell line name hTERT-HPNE E6/E7/K-RasG12D/st
Accession CVCL_C470
Resource Identification Initiative To cite this cell line use: hTERT-HPNE E6/E7/K-RasG12D/st (RRID:CVCL_C470)
Comments Doubling time: ~31 hours (ATCC=CRL-4039).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6407; KRAS (Note=With p.Gly12Asp (c.35G>A)).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Cell type: Pancreatic ductal cell; CL=CL_0002079.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C469 (hTERT-HPNE E6/E7/K-RasG12D)
Sex of cell Male
Age at sampling 52Y
Category Transformed cell line
STR profile Source(s): ATCC=CRL-4039

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,22
D3S135815
D5S81811
D7S8209,10
D8S117910,13
D13S31712,13
D16S53912,13
D18S5113,16
D19S43312,16.2
D21S1130
FGA23,24
Penta D11
Penta E7,10
TH018,9
TPOX8,11
vWA17

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Publications

PubMed=17332339; DOI=10.1158/0008-5472.CAN-06-3752
Paul M. Campbell, Angela L. Groehler, Kwang M. Lee, Michel M. Ouellette, Vladimir Khazak, Channing Joseph Der;
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Cancer Res. 67:2098-2106(2007)

Cross-references
Cell line collections (Providers) ATCC; CRL-4039
Encyclopedic resources Wikidata; Q54896628
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number17