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Cellosaurus hTERT-HPNE (CVCL_C466)

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Cell line name hTERT-HPNE
Synonyms hTERT-Human Pancreatic Nestin-Expressing cells
Accession CVCL_C466
Resource Identification Initiative To cite this cell line use: hTERT-HPNE (RRID:CVCL_C466)
Comments Doubling time: ~26 hours (PBCF).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Cell type: Pancreatic ductal cell; CL=CL_0002079.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C467 (hTERT-HPNE E6/E7)
Sex of cell Male
Age at sampling 52Y
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4023

Markers:
AmelogeninX,Y
CSF1PO12
D2S133817,22
D3S135815
D5S81811
D7S8209,10
D8S117910,13
D13S31712,13
D16S53912,13
D18S5113,16
D19S43312,16.2
D21S1130
FGA23,24
Penta D11
Penta E7,10
TH018,9
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Web pages Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544518
Publications

PubMed=12589817; DOI=10.1016/S0006-291X(03)00086-X
Kwang M. Lee, Christophe L. Nguyen, Alexis B. Ulrich, Parviz M. Pour, Michel M. Ouellette;
Immortalization with telomerase of the nestin-positive cells of the human pancreas.
Biochem. Biophys. Res. Commun. 301:1038-1044(2003)

PubMed=17332339; DOI=10.1158/0008-5472.CAN-06-3752
Paul M. Campbell, Angela L. Groehler, Kwang M. Lee, Michel M. Ouellette, Vladimir Khazak, Channing Joseph Der;
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Cancer Res. 67:2098-2106(2007)

Cross-references
Cell line collections (Providers) ATCC; CRL-4023
Anatomy/cell type resources BTO; BTO_0006092
Biological sample resources BioSample; SAMN05292450
Encyclopedic resources Wikidata; Q54896625
Experimental variables resources EFO; EFO_0022415
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number15