Cellosaurus cell line CuFi-3 (CVCL

Cellosaurus CuFi-3 (CVCL_C458)

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Cell line name

CuFi-3

Synonyms

CuFi3; Cystic Fibrosis, University of Iowa-3

Accession

CVCL_C458

Resource Identification Initiative

To cite this cell line use: CuFi-3 (RRID:CVCL_C458)

Comments

Karyotypic information: 48,XY,+5,+20 [10] (PubMed=12676769).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.

Sequence variations

Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Heterozygous (PubMed=12676769).
Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Arg553Ter (c.1657C>T); ClinVar=VCV000007122; Zygosity=Heterozygous (PubMed=12676769).

Disease

Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

15Y

Category

Transformed cell line

STR profile

Source(s): ATCC=CRL-4014

Markers:

Amelogenin	X,Y
CSF1PO	10,13
D5S818	11,12
D7S820	10,11
D13S317	11,12
D16S539	12,13
TH01	9,9.3
TPOX	10,11
vWA	16,19

Publications

PubMed=12676769; DOI=10.1152/ajplung.00355.2002
Joseph Zabner, Phil Karp, Michael Seiler, Stacia L. Phillips, Calista J. Mitchell, Mimi T. Saavedra, Michael James Welsh, Aloysius J. Klingelhutz;
Development of cystic fibrosis and noncystic fibrosis airway cell lines.
Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L844-L854(2003)

PubMed=17191107; DOI=10.1007/s10238-006-0116-5
Sergio Gambardella, Michela Biancolella, Maria Rosaria D'Apice, Francesca Amati, Federica Sangiuolo, Alessio Farcomeni, Giovanni Chillemi, Susana Bueno, Alessandro Desideri, Giuseppe Novelli;
Gene expression profile study in CFTR mutated bronchial cell lines.
Clin. Exp. Med. 6:157-165(2006)

Cross-references

Cell line collections (Providers)

ATCC; CRL-4014 - Discontinued
CancerTools; 154446

Biological sample resources

BioSample; SAMN03471723

Encyclopedic resources

Wikidata; Q54814856

Entry history

Entry creation

22-Oct-2012

Last entry update

14-Aug-2025

Version number