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Cellosaurus RK35 (CVCL_C3VG)

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Cell line name RK35
Accession CVCL_C3VG
Resource Identification Initiative To cite this cell line use: RK35 (RRID:CVCL_C3VG)
Comments Group: Patented cell line.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized domagrozumab (PF-06252616) therapeutic antibody which was used in clinical trials for the treatment of Duchenne muscular dystrophy.
Monoclonal antibody isotype: Not specified.
Monoclonal antibody target: UniProtKB; O14793; Human MSTN.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=16837207; DOI=10.1016/j.nbd.2006.05.009
Erika L.F. Holzbaur, David S. Howland, Nicholas Weber, Karen Wallace, Yi-Jin She, Seung Poon Kwak, Lioudmila Gennadievna Tchistiakova, Erin Murphy, Joseph Hinson, Riyez Karim, Xiang-Yang Tan ...Show all 19 authors... , Pamela Kelley, Kevin C. McGill, Gareth Williams, Carl Hobbs, Patrick Doherty, Margaret M. Zaleska, Menelas Nicolas Pangalos, Frank S. Walsh; Show fewer authors
Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis.
Neurobiol. Dis. 23:697-707(2006)

Patent=US9926368
Frank S. Walsh, Margaret M. Zaleska, David S. Howland, Lioudmila Gennadievna Tchistiakova, Riyez Karim, Pamela Kelley, Xiang-Yang Tan, Seung Poon Kwak, Menelas Nicolas Pangalos;
Method for treating muscle wasting syndrome using antagonist antibodies against GDF-8.
Patent number US9926368, 27-Mar-2018

Cross-references
Biological sample resources ABCD; ABCD_AI744
Encyclopedic resources Wikidata; Q116050176
Entry history
Entry creation15-Dec-2022
Last entry update21-Mar-2023
Version number2