Cellosaurus cell line HEK293 GOT2 KO clone A7 (CVCL

Cellosaurus HEK293 GOT2 KO clone A7 (CVCL_C3NI)

Cross-references
Cell line name	HEK293 GOT2 KO clone A7
Accession	CVCL_C3NI
Resource Identification Initiative	To cite this cell line use: HEK293 GOT2 KO clone A7 (RRID:CVCL_C3NI)
Comments	Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4433; GOT2. Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0045 (HEK293)
Sex of cell	Female
Age at sampling	Fetus
Category	Transformed cell line
Publications	PubMed=31422819; DOI=10.1016/j.ajhg.2019.07.015; PMCID=PMC6732527 Clara D.M. van Karnebeek, Ruben J. Ramos, Xiao-Yan Wen, Maja Tarailo-Graovac, Joseph G. Gleeson, Cristina Skrypnyk, Koroboshka Brand-Arzamendi, Farhad Karbassi, Mahmoud Y. Issa, Robin van der Lee, Britt I. Drogemoller ...Show all 33 authors... , Janet Koster, Justine Rousseau, Philippe M. Campeau, You-Dong Wang, Feng Cao, Meng Li, Jos Ruiter, Jolita Ciapaite, Leo A.J. Kluijtmans, Michel A.A.P. Willemsen, Judith J.M. Jans, Colin J.D. Ross, Liesbeth T. Wintjes, Richard J. Rodenburg, Marleen C.D.G. Huigen, Zheng-Ping Jia, Hans R. Waterham, Wyeth W. Wasserman, Ronald J.A. Wanders, Nanda M. Verhoeven-Duif, Maha S. Zaki, Ron A. Wevers; Show fewer authors Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy. Am. J. Hum. Genet. 105:534-548(2019)
Cell line collections (Providers)	ABM; T6426
Encyclopedic resources	Wikidata; Q116049301
Entry history
Entry creation	15-Dec-2022
Last entry update	14-Aug-2025
Version number	5