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Cellosaurus MCF7-parkin clone 7 (CVCL_C3IC)

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Cell line name MCF7-parkin clone 7
Synonyms MCF7-PK7; MCF7-PK#7
Accession CVCL_C3IC
Resource Identification Initiative To cite this cell line use: MCF7-parkin clone 7 (RRID:CVCL_C3IC)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:8607; PRKN (Note=With a N-terminal FLAG tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=20630868; DOI=10.1074/jbc.M110.108241; PMCID=PMC2937954
Shiam-Peng Tay, Calvin W.-S. Yeo, Chou Chai, Pei-Jou Chua, Hui-Mei Tan, Alex X.-Y. Ang, Daniel L.-H. Yip, Jian-Xiong Sung, Puay Hoon Tan, Boon-Huat Bay, Siew-Heng Wong ...Show all 14 authors... , Carol Tang, Jeanne M.-M. Tan, Kah-Leong Lim; Show fewer authors
Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells.
J. Biol. Chem. 285:29231-29238(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IC
Encyclopedic resources Wikidata; Q114312272
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9