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Cellosaurus SH-SY5Y-parkin clone 6 (CVCL_C3I8)

[Text version]
Cell line name SH-SY5Y-parkin clone 6
Synonyms SH-Parkin 6
Accession CVCL_C3I8
Resource Identification Initiative To cite this cell line use: SH-SY5Y-parkin clone 6 (RRID:CVCL_C3I8)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:8607; PRKN (Note=With a N-terminal FLAG tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0019 (SH-SY5Y)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Publications

PubMed=16278233; DOI=10.1093/hmg/ddi413
Cheng Wang, Han Seok Ko, Bobby Thomas, Fai Tsang, Katherine Chee-Meng Chew, Shiam-Peng Tay, Michelle W.L. Ho, Tit-Meng Lim, Tuck-Wah Soong, Olga Pletnikova, Juan Troncoso ...Show all 14 authors... , Valina L. Dawson, Ted Murray Dawson, Kah-Leong Lim; Show fewer authors
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Hum. Mol. Genet. 14:3885-3897(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3I8
Encyclopedic resources Wikidata; Q114312999
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number8