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Cellosaurus U-251MG-PARK2 (CVCL_C3I4)

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Cell line name U-251MG-PARK2
Synonyms U251-PARK2; U251-park2
Accession CVCL_C3I4
Resource Identification Initiative To cite this cell line use: U-251MG-PARK2 (RRID:CVCL_C3I4)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:8607; PRKN.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
Publications

PubMed=25877876; DOI=10.1158/0008-5472.CAN-14-1433; PMCID=PMC4417379
De-Chen Lin, Liang Xu, Ye Chen, Hai-Yan Yan, Masaharu Hazawa, Ngan B. Doan, Jonathan William Said, Ling-Wen Ding, Li-Zhen Liu, Henry He Yang, Shi-Zhu Yu ...Show all 14 authors... , Michael Kahn, Dong Yin, Harold Phillip Koeffler; Show fewer authors
Genomic and functional analysis of the E3 ligase PARK2 in glioma.
Cancer Res. 75:1815-1827(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3I4
Encyclopedic resources Wikidata; Q114313140
Gene expression databases GEO; GSM1517806
GEO; GSM1517807
GEO; GSM1517808
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9