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Cellosaurus HT1376 FOXP3 (CVCL_C3H1)

[Text version]
Cell line name HT1376 FOXP3
Accession CVCL_C3H1
Resource Identification Initiative To cite this cell line use: HT1376 FOXP3 (RRID:CVCL_C3H1)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6106; FOXP3.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gln702Ter (c.2104C>T); ClinVar=VCV000428683; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro250Leu (c.749C>T); ClinVar=VCV000420136; Zygosity=Unspecified (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1292 (HT-1376)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=27189164; DOI=10.1158/1078-0432.CCR-15-2581
Han-Wei Zhang, Kris Prado, Kelvin X. Zhang, Elizabeth M. Peek, Jane Lee, Xiao-Yan Wang, Jiao-Ti Huang, Gang Li, Matteo Pellegrini, Arnold I. Chin;
Biased expression of the FOXP3Delta3 isoform in aggressive bladder cancer mediates differentiation and cisplatin chemotherapy resistance.
Clin. Cancer Res. 22:5349-5361(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3H1
Encyclopedic resources Wikidata; Q114311671
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number8