Cellosaurus cell line ASP3-UPIC (CVCL

Cellosaurus ASP3-UPIC (CVCL_C3G5)

Cross-references
Cell line name	ASP3-UPIC
Synonyms	Alport Syndrome Patient 3-Urine Podocyte Immortalized Cell line
Accession	CVCL_C3G5
Resource Identification Initiative	To cite this cell line use: ASP3-UPIC (RRID:CVCL_C3G5)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Omics: Transcriptomics; RNAseq. Miscellaneous: As no cell line name was provided in the paper, we assigned the name based on the abbreviation of the cell line description. Derived from site: In situ; Urine; UBERON=UBERON_0001088. Cell type: Podocyte; CL=CL_0000653.
Sequence variations	Mutation; HGNC; HGNC:2207; COL4A5; Simple; p.Gly849Glu (c.2546G>A); Zygosity=Hemizygous (PubMed=32652570).
Disease	Alport syndrome (NCIt: C34842) Alport syndrome (ORDO: Orphanet_63)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	22Y
Category	Conditionally immortalized cell line
Publications	PubMed=32652570; DOI=10.1002/path.5496; PMCID=PMC7589231 Corinne Iampietro, Linda Bellucci, Fanny O. Arcolino, Maddalena Arigoni, Luca Alessandri, Yonathan Gomez, Elli Papadimitriou, Raffaele A. Calogero, Enrico Cocchi, Lambertus P.W.J. van den Heuvel, Elena N. Levtchenko, Benedetta Bussolati; Molecular and functional characterization of urine-derived podocytes from patients with Alport syndrome. J. Pathol. 252:88-100(2020)
Encyclopedic resources	Wikidata; Q114310632
Gene expression databases	GEO; GSM3933300 GEO; GSM3933301 GEO; GSM3933302
Entry history
Entry creation	22-Sep-2022
Last entry update	14-Aug-2025
Version number	9