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Cellosaurus ASP2-UPIC (CVCL_C3G4)

[Text version]
Cell line name ASP2-UPIC
Synonyms Alport Syndrome Patient 2-Urine Podocyte Immortalized Cell line
Accession CVCL_C3G4
Resource Identification Initiative To cite this cell line use: ASP2-UPIC (RRID:CVCL_C3G4)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Omics: Transcriptomics; RNAseq.
Miscellaneous: As no cell line name was provided in the paper, we assigned the name based on the abbreviation of the cell line description.
Derived from site: In situ; Urine; UBERON=UBERON_0001088.
Cell type: Podocyte; CL=CL_0000653.
Sequence variations
  • Mutation; HGNC; HGNC:2207; COL4A5; Simple; p.Gly926Alafs*70 (c.2777del); Zygosity=Heterozygous (PubMed=32652570).
Disease Alport syndrome (NCIt: C34842)
Alport syndrome (ORDO: Orphanet_63)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 11Y
Category Conditionally immortalized cell line
Publications

PubMed=32652570; DOI=10.1002/path.5496; PMCID=PMC7589231
Corinne Iampietro, Linda Bellucci, Fanny O. Arcolino, Maddalena Arigoni, Luca Alessandri, Yonathan Gomez, Elli Papadimitriou, Raffaele A. Calogero, Enrico Cocchi, Lambertus P.W.J. van den Heuvel, Elena N. Levtchenko, Benedetta Bussolati;
Molecular and functional characterization of urine-derived podocytes from patients with Alport syndrome.
J. Pathol. 252:88-100(2020)

Cross-references
Encyclopedic resources Wikidata; Q114310631
Gene expression databases GEO; GSM3933294
GEO; GSM3933295
GEO; GSM3933296
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9