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Cellosaurus CWRU-C57BL/6-IPTEC (CVCL_C3FC)

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Cell line name CWRU-C57BL/6-IPTEC
Synonyms Case Western Reserve University-C57BL/6-Immortalized Proximal Tubule Epithelial Cell line
Accession CVCL_C3FC
Resource Identification Initiative To cite this cell line use: CWRU-C57BL/6-IPTEC (RRID:CVCL_C3FC)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Omics: Transcriptomics; RNAseq.
Miscellaneous: As no cell line name was provided in the paper, we assigned the name based on the abbreviation of the institution and of the cell line description.
Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6J.
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Transformed cell line
Publications

PubMed=22020933; DOI=10.1074/jbc.M110.212845; PMCID=PMC3234923
Bassam G. Abu Jawdeh, Shenaz Khan, Isabelle Deschenes, Malcolm Hoshi, Monu Goel, Jeffrey T. Lock, Krekwit Shinlapawittayatorn, Gerald Thomas Babcock, Sujata Lakhe-Reddy, Garren James DeCaro, Satya Prakash Yadav ...Show all 16 authors... , Maradumane L. Mohan, Sathyamangla V. Naga Prasad, William P. Schilling, Eckhard Ficker, Jeffrey R. Schelling; Show fewer authors
Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival.
J. Biol. Chem. 286:42435-42445(2011)

PubMed=24531551; DOI=10.1172/JCI71863; PMCID=PMC3934167
Shenaz Khan, Bassam G. Abu Jawdeh, Monu Goel, William P. Schilling, Mark D. Parker, Michelle A. Puchowicz, Satya Prakash Yadav, Raymond Clement Harris, Ashraf El-Meanawy, Malcolm Hoshi, Krekwit Shinlapawittayatorn ...Show all 14 authors... , Isabelle Deschenes, Eckhard Ficker, Jeffrey R. Schelling; Show fewer authors
Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.
J. Clin. Invest. 124:1057-1068(2014)

PubMed=33122286; DOI=10.1681/ASN.2020010009; PMCID=PMC7894662
Syed J. Khundmiri, Li-He Chen, Eleanor D. Lederer, Chin-Rang Yang, Mark A. Knepper;
Transcriptomes of major proximal tubule cell culture models.
J. Am. Soc. Nephrol. 32:86-97(2021)

Cross-references
Encyclopedic resources Wikidata; Q114311315
Gene expression databases GEO; GSM4009074
GEO; GSM4009075
GEO; GSM4009076
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7