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Cellosaurus NK-NJ (CVCL_C3ES)

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Cell line name NK-NJ
Accession CVCL_C3ES
Resource Identification Initiative To cite this cell line use: NK-NJ (RRID:CVCL_C3ES)
Comments Population: Chinese.
Characteristics: IL2 dependent.
Doubling time: 48 hours (PubMed=36520345).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: NK T-cell; CL=CL_0000814.
Sequence variations
  • Mutation; HGNC; HGNC:1133; BTK; Simple; p.Met228Ile (c.684G>A); ClinVar=VCV001686397; Zygosity=Heterozygous (PubMed=36520345).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ile11Glufs*2 (c.30_54del); Zygosity=Heterozygous (PubMed=36520345).
  • Mutation; HGNC; HGNC:11367; STAT5B; Simple; p.Asn642His (c.1924A>C); ClinVar=VCV000657518; Zygosity=Heterozygous (PubMed=36520345).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=36520345).
Disease Nasal type extranodal NK/T-cell lymphoma (NCIt: C4684)
Extranodal nasal NK/T cell lymphoma (ORDO: Orphanet_86879)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=36520345; DOI=10.1007/s13577-022-00841-y
Jin-Hua Liang, Wei-Ting Wang, Kai-Xin Du, Tong-Yao Xing, Yan Wang, Hui Wang, Lu Liu, Rui Guo, Yang Shao, Jun-Heng Liang, Yue Li ...Show all 15 authors... , Hao-Rui Shen, Li Wang, Jian-Yong Li, Wei Xu; Show fewer authors
Establishment and comprehensive analysis of a new human cell line (NK-NJ) with NK-cell characteristics established from extranodal natural killer cell lymphoma/leukemia.
Hum. Cell 36:835-846(2023)

Cross-references
Encyclopedic resources Wikidata; Q123033194
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4