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Cellosaurus A549 RFP-STAT3 (CVCL_C3C8)

[Text version]
Cell line name A549 RFP-STAT3
Accession CVCL_C3C8
Resource Identification Initiative To cite this cell line use: A549 RFP-STAT3 (RRID:CVCL_C3C8)
Comments Population: Caucasian.
Characteristics: Edited by ZFN at the STAT3 locus to insert a TagRFP construct at the N-terminus of the gene.
Transfected with: UniProtKB; D0VX33; Entacmaea quadricolor FP480 (with p.Thr6Lys, p.Gln41Met, p.His67Ser, p.Gln134Lys, p.Ala142Pro, p.His143Ser, p.Met146Lys, p.Tyr148Lys, p.Ala158Val, p.Leu160Met, p.Tyr197Arg, p.Arg201Ile, p.Val211Trp and p.Cys222Ser = TagRFP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Web pages https://www.sigmaaldrich.com/catalog/product/sigma/cll1140
Cross-references
Cell line databases/resources cancercelllines; CVCL_C3C8
Encyclopedic resources Wikidata; Q114310529
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5