Cellosaurus cell line SKOV3-GFP-HER2 (CVCL

Cellosaurus SKOV3-GFP-HER2 (CVCL_C3C2)

[Text version]

Cell line name

SKOV3-GFP-HER2

Accession

CVCL_C3C2

Resource Identification Initiative

To cite this cell line use: SKOV3-GFP-HER2 (RRID:CVCL_C3C2)

Comments

Population: Caucasian.
Characteristics: Edited by ZFN at the ERBB2 locus to insert a TagGFP2 construct at the C-terminus of the gene.
Transfected with: UniProtKB; Q8WTC6; Aequorea macrodactyla GFP (with p.Lys3Gly, p.Thr9Ala, p.Ser65Cys, p.Phe99Gln, p.Met128Lys, p.Asn144Ser, p.Met153Arg, p.Lys162Glu, p.Val163Ala, p.Ile167Thr, p.Ala206Lys, p.Thr214Ala, p.Phe220Leu, p.Phe223Ser, p.Gly228Cys and Lys238Arg = TagGFP2).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).

Disease

Ovarian serous cystadenocarcinoma (NCIt: C7978)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0532 (SK-OV-3)
Children:

CVCL_C3C3 (SKOV3-GFP-HER2 RFP-EGFR)

Sex of cell

Female

Age at sampling

64Y