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Cellosaurus Mel290 (CVCL_C304)

[Text version]
Cell line name Mel290
Synonyms MEL290; Mel-290; Mel 290; MEL 290
Accession CVCL_C304
Resource Identification Initiative To cite this cell line use: Mel290 (RRID:CVCL_C304)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Ksander, Bruce R.; Schepens Eye Research Institute; Boston; USA.
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Eye, uvea; UBERON=UBERON_0001768.
Sequence variations
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gln288Glu (c.862C>G); Zygosity=Unspecified (PubMed=39042403).
  • Mutation; HGNC; HGNC:9284; PPP1R10; Simple; p.Met528Thr (c.1583T>C); Zygosity=Unspecified (PubMed=39042403).
Disease Uveal melanoma (NCIt: C7712)
Uveal melanoma (ORDO: Orphanet_39044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002016; ICLC=HTL12002; PubMed=22236444

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,18
D5S81810,12
D7S82011,12
D8S117911,13
D13S3178,11
D16S53911,13
D18S5114,15
D21S1128,32.1
FGA18,20
Penta D10,11
Penta E5,8
TH016,9
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
Jason S. White, Robert L. Becker, Ian W. McLean, Alison E. Director-Myska, Joginder Nath;
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x; PMCID=PMC3288394
Klaus Georg Griewank, Xiao-Xing Yu, Jahan S. Khalili, Mustafa Mert Sozen, Katherine Stemke-Hale, Chantale Bernatchez, Seth Wardell, Boris C. Bastian, Scott E. Woodman;
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676
Ken Dutton-Regester, Darryl Irwin, Priscilla Hunt, Lauren G. Aoude, Varsha Tembe, Gulietta M. Pupo, Cathy Lanagan, Candace D. Carter, Linda O'Connor, Michael O'Rourke, Richard Anthony Scolyer ...Show all 15 authors... , Graham J. Mann, Christopher W. Schmidt, Adrian Herington, Nicholas K. Hayward; Show fewer authors
A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.
Mol. Cancer Ther. 11:888-897(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Adriana Amaro, Valentina Mirisola, Giovanna Angelini, Alessandra Musso, Francesca Isabella Tosetti, Alessia Isabella Esposito, Patrizia Perri, Francesco Baldo Lanza, Francesca Nasciuti, Carlo Mosci, Roberto Puzone ...Show all 15 authors... , Sandra Salvi, Mauro Truini, Alessandro Poggi, Ulrich Pfeffer; Show fewer authors
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

PubMed=28018010; PMCID=PMC5161001
Martine Johanna Jager, Jose Antonio Bermudez Magner, Bruce R. Ksander, Sander R. Dubovy;
Uveal melanoma cell lines: where do they come from? (an American Ophthalmological Society thesis).
Trans. Am. Ophthalmol. Soc. 114:T5-T5(2016)

PubMed=39042403; DOI=10.1167/iovs.65.8.37; PMCID=PMC11268447
Maria Chiara Gelmi, Arnoud H. de Ru, Peter A. van Veelen, Rayman T.N. Tjokrodirijo, Marc-Henri Stern, Alexandre Houy, Robert M. Verdijk, T.H. Khanh Vu, Bruce R. Ksander, Jolanda Vaarwater, Emine Kilic ...Show all 13 authors... , Erwin Brosens, Martine Johanna Jager; Show fewer authors
Protein and mRNA expression in uveal melanoma cell lines are related to GNA and BAP1 mutation status.
Invest. Ophthalmol. Vis. Sci. 65:37-37(2024)

Cross-references
Cell line collections (Providers) ICLC; HTL12002
Cell line databases/resources CLDB; cl7222
cancercelllines; CVCL_C304
Cell_Model_Passport; SIDM01792
DepMap; ACH-002016
Encyclopedic resources Wikidata; Q54905165
Polymorphism and mutation databases Cosmic; 916141
Cosmic; 1628406
Cosmic; 1669125
Proteomic databases PRIDE; PXD051055
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number20