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Cellosaurus HeLa S3 penta KO-ULK1/ULK2 DKO (CVCL_C2VS)

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Cell line name HeLa S3 penta KO-ULK1/ULK2 DKO
Synonyms HeLa S3 ULK1/2 DKO/penta KO
Accession CVCL_C2VS
Resource Identification Initiative To cite this cell line use: HeLa S3 penta KO-ULK1/ULK2 DKO (RRID:CVCL_C2VS)
Comments Population: African American.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:29912; CALCOCO2.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6746; NBR1.
Knockout cell: Method=TALEN; HGNC; HGNC:17142; OPTN.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11280; SQSTM1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11575; TAX1BP1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12558; ULK1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13480; ULK2.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C2VN (HeLa S3 penta KO)
Children:
CVCL_C2VT (HeLa S3 penta KO-TBK1/ULK1/ULK2 TKO)CVCL_C9DW (HeLa S3 penta KO-ULK1/ULK2 DKO-AZI2/TBKBP1 DKO)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

DOI=10.1101/2023.09.25.559255
Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Emily Maria Watts, Stephen Shoebridge, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens;
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD.
bioRxiv 2023:09.25.559255-09.25.559255(2023)

Cross-references
Encyclopedic resources Wikidata; Q114311589
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number8