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Cellosaurus SJ-HGGX42c (CVCL_C1NL)

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Cell line name SJ-HGGX42c
Synonyms SJHGG054830_C2
Accession CVCL_C1NL
Resource Identification Initiative To cite this cell line use: SJ-HGGX42c (RRID:CVCL_C1NL)
Comments Characteristics: Derived from a patient-derived xenograft.
Doubling time: 6.1 days (PubMed=34215733).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; 8DNLG; YFP (Note=EYFP, yellow fluorescent protein derived from GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, cerebral cortex; UBERON=UBERON_0000956.
Sequence variations
  • Mutation; HGNC; HGNC:20893; BCOR; Simple; p.Ser177fs (c.529_530delAG); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Gly35Arg (c.103G>A) (H3.3G34R); ClinVar=VCV000438766; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu265del (c.792_794delTCT); Zygosity=Heterozygous (PubMed=34215733).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 13-14Y
Category Cancer cell line
STR profile Source(s): PubMed=34215733

Markers:
AmelogeninX,Y
CSF1PO10,11
D3S135814,15
D5S81813
D7S82011,12
D8S117913
D13S31713
D16S5399,11
D18S5112,18
D21S1129,30
TH016,9.3
TPOX9,11
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; PBTP; -; https://pbtp.stjude.cloud/sample-details/29986/baker/SJHGG059115/SJ-HGGX42/Cell%20Line
Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
Chen He, Ke Xu, Xiao-Yan Zhu, Paige S. Dunphy, Brian Gudenas, Wen-Wei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn Heath Kasper, Jun-Yuan Zhang ...Show all 40 authors... , Xiao-Yu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Ying-Zhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh Ananthram Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick A. Boop, Amar Gajjar, Jing-Hui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman 3rd, Martine Francoise Roussel, Paul A. Northcott, Tao-Sheng Chen, Zoran Rankovic, Gang Wu, Jason Cheng-Hsuan Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker; Show fewer authors
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NL
Encyclopedic resources Wikidata; Q114313026
Entry history
Entry creation22-Sep-2022
Last entry update14-Aug-2025
Version number9