Cellosaurus cell line SJ-HGGX2c (CVCL

Cellosaurus SJ-HGGX2c (CVCL_C1NJ)

[Text version]

Cell line name

SJ-HGGX2c

Synonyms

SJHGG009024_C2

Accession

CVCL_C1NJ

Resource Identification Initiative

To cite this cell line use: SJ-HGGX2c (RRID:CVCL_C1NJ)

Comments

Characteristics: Derived from a patient-derived xenograft.
Doubling time: 8.2 days (PubMed=34215733).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.

Sequence variations

Mutation; HGNC; HGNC:8803; PDGFRA; Simple; p.Asn659Lys (c.1977C>G); ClinVar=VCV000375902; Zygosity=Homozygous (PubMed=34215733).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Trp (c.405C>G); ClinVar=VCV000376561; Zygosity=Homozygous (PubMed=34215733).

Disease

Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

4-5Y

Category

Cancer cell line

STR profile

Source(s): PubMed=34215733

Markers:

Amelogenin	X,Y
CSF1PO	10,11
D3S1358	15,16
D5S818	10,11
D7S820	10
D8S1179	15
D13S317	11
D16S539	9,12
D18S51	16
D21S11	30
FGA	24,25
Penta D	2.2,5
Penta E	8
TH01	6,9.3
TPOX	10,11
vWA	15,16

Web pages

Provider; PBTP; -; https://pbtp.stjude.cloud/sample-details/29958/baker/SJHGG009024/SJ-HGGX2/Cell%20Line

Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
Chen He, Ke Xu, Xiao-Yan Zhu, Paige S. Dunphy, Brian Gudenas, Wen-Wei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn Heath Kasper, Jun-Yuan Zhang ...Show all 40 authors... , Xiao-Yu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Ying-Zhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick A. Boop, Amar Gajjar, Jing-Hui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman 3rd, Martine Francoise Roussel, Paul A. Northcott, Tao-Sheng Chen, Zoran Rankovic, Gang Wu, Jason Cheng-Hsuan Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker; Show fewer authors
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C1NJ

Encyclopedic resources

Wikidata; Q114313024

Entry history

Entry creation

22-Sep-2022

Last entry update

10-Apr-2025

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