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Cellosaurus SJ-DIPGX9c (CVCL_C1NI)

[Text version]
Cell line name SJ-DIPGX9c
Synonyms SJHGG010327_C3
Accession CVCL_C1NI
Resource Identification Initiative To cite this cell line use: SJ-DIPGX9c (RRID:CVCL_C1NI)
Comments Characteristics: Derived from a patient-derived xenograft.
Doubling time: 9.1 days (PubMed=34215733).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; HGNC:171; ACVR1; Simple; p.Gly328Glu (c.983G>A); ClinVar=VCV000029595; Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:4776; H3C2; Simple; p.Lys28Met (c.83A>T) (H3.1K27M); Zygosity=Heterozygous (PubMed=34215733).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (PubMed=34215733).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=34215733

Markers:
AmelogeninX
CSF1PO10,13
D3S135816,17
D5S81810,11
D7S82010,12
D8S117913,14
D13S31710,13
D16S53912,14
D18S5118,19
D21S1127,30
FGA20,24
Penta D12
Penta E14,17
TH016
TPOX8,10
vWA14,17

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Web pages Provider; PBTP; -; https://pbtp.stjude.cloud/sample-details/29962/baker/SJHGG010327/SJ-DIPGX9/Cell%20Line
Publications

PubMed=34215733; DOI=10.1038/s41467-021-24168-8; PMCID=PMC8253809
Chen He, Ke Xu, Xiao-Yan Zhu, Paige S. Dunphy, Brian Gudenas, Wen-Wei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn Heath Kasper, Jun-Yuan Zhang ...Show all 40 authors... , Xiao-Yu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Ying-Zhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick A. Boop, Amar Gajjar, Jing-Hui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman 3rd, Martine Francoise Roussel, Paul A. Northcott, Tao-Sheng Chen, Zoran Rankovic, Gang Wu, Jason Cheng-Hsuan Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker; Show fewer authors
Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
Nat. Commun. 12:4089.1-4089.17(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NI
Encyclopedic resources Wikidata; Q114313023
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7