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Cellosaurus SNU-668 Ola-R (CVCL_C1NC)

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Cell line name SNU-668 Ola-R
Synonyms SNU-668/olaparib-resistant; Olaparib-resistant SNU-668
Accession CVCL_C1NC
Resource Identification Initiative To cite this cell line use: SNU-668 Ola-R (RRID:CVCL_C1NC)
Comments Population: Korean.
Selected for resistance to: ChEBI; CHEBI_83766; Olaparib.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000177777; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Asn (c.644G>A); ClinVar=VCV000376662; Zygosity=Homozygous (from parent cell line).
Disease Gastric signet ring cell adenocarcinoma (NCIt: C5250)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5081 (SNU-668)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=32028591; DOI=10.3390/cancers12020334; PMCID=PMC7072281
Jin Won Kim, Ahrum Min, Seock-Ah Im, Hyemin Jang, Yu Jin Kim, Hee-Jun Kim, Kyung-Hun Lee, Tae-Yong Kim, Keun Wook Lee, Do-Youn Oh, Jee-Hyun Kim, Yung-Jue Bang;
TDP1 and TOP1 modulation in olaparib-resistant cancer determines the efficacy of subsequent chemotherapy.
Cancers (Basel) 12:334.1-334.17(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1NC
Encyclopedic resources Wikidata; Q114313043
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6