Cellosaurus logo
expasy logo

Cellosaurus TT10630 (CVCL_C1ML)

[Text][XML][JSON]
Cell line name TT10630
Accession CVCL_C1ML
Resource Identification Initiative To cite this cell line use: TT10630 (RRID:CVCL_C1ML)
Comments Population: Chinese.
Doubling time: 43.1 +- 1.6 hours (PubMed=29100338).
Derived from site: In situ; Brainstem, pons; UBERON=UBERON_0000988.
Sequence variations
  • Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=29100338).
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Ser516Ter (c.1547C>G); Zygosity=Unspecified (PubMed=29100338).
Disease Diffuse intrinsic pontine glioma (NCIt: C94764)
Diffuse intrinsic pontine glioma (ORDO: Orphanet_497188)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): PubMed=34732238

Markers:
AmelogeninX
CSF1PO11,13
D5S8189,11
D7S8208,13
D13S3178
D16S53910,12
D21S1131.2,33.2
TH017,8
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=29100338; DOI=10.18632/oncotarget.19656; PMCID=PMC5652732
Cheng Xu, Xiao-Qing Liu, Yi-Bo Geng, Qing-Ran Bai, Chang-Cun Pan, Yu Sun, Xin Chen, Hai Yu, Yu-Liang Wu, Peng Zhang, Wen-Hao Wu ...Show all 23 authors... , Yu Wang, Zhen Wu, Jun-Ting Zhang, Zhao-Hui Wang, Rui Yang, Jenna Lewis, Darell Doty Bigner, Fang-Ping Zhao, Yi-Ping He, Hai Yan, Qin Shen, Li-Wei Zhang; Show fewer authors
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors.
Oncotarget 8:76644-76655(2017)

PubMed=34732238; DOI=10.1186/s40478-021-01270-y; PMCID=PMC8565061
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Li-Wei Zhang, Matthew S. Waitkus, Yi-Ping He, Hai Yan;
TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Acta Neuropathol. Commun. 9:178.1-178.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1ML
Encyclopedic resources Wikidata; Q114313131
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6