Cellosaurus cell line ALL-VG TKI-resistant (CVCL

Cellosaurus ALL-VG TKI-resistant (CVCL_C1MF)

Cross-references
Cell line name	ALL-VG TKI-resistant
Accession	CVCL_C1MF
Resource Identification Initiative	To cite this cell line use: ALL-VG TKI-resistant (RRID:CVCL_C1MF)
Comments	Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571). Omics: Genomics; Whole exome sequencing. Omics: Proteomics; 2DE-MS. Omics: Variations; SNP array analysis. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene deletion; HGNC; HGNC:1785; CDKN1B; Zygosity=Unspecified (from parent cell line). Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Unspecified (from parent cell line). Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Unspecified (from parent cell line). Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:3495; ETV6; Name(s)=ETV6-ABL1 (PubMed=28650474). Mutation; HGNC; HGNC:4396; GNB1; Simple; p.Lys89Met (c.266A>T); ClinVar=VCV001360749; Zygosity=Heterozygous; Note=Involved in imatinib resistance (PubMed=28650474).
Disease	Adult B acute lymphoblastic leukemia (NCIt: C9143) Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_C1ME (ALL-VG)
Sex of cell	Male
Age at sampling	30Y
Category	Cancer cell line
Publications	PubMed=28650474; DOI=10.1038/onc.2017.210; PMCID=PMC5666322 Olga Zimmermannova, Eliska Doktorova, Jan Stuchly, Veronika Kanderova, Daniela Kuzilkova, Hynek Strnad, Julia Starkova, Meritxell Alberich-Jorda, J.H. Frederik Falkenburg, Jan Trka, Jiri Petrak ...Show all 13 authors... , Jan Zuna, Marketa Zaliova; Show fewer authors An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia. Oncogene 36:5985-5994(2017)
Cell line databases/resources	cancercelllines; CVCL_C1MF
Encyclopedic resources	Wikidata; Q114310623
Entry history
Entry creation	22-Sep-2022
Last entry update	10-Apr-2025
Version number	7