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Cellosaurus H446/VP (CVCL_C1MD)

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Cell line name H446/VP
Accession CVCL_C1MD
Resource Identification Initiative To cite this cell line use: H446/VP (RRID:CVCL_C1MD)
Comments Population: Caucasian.
Doubling time: 35.7 hours (CelloPub=CLPUB00716).
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:6728; LY6H + HGNC; HGNC:9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1562 (NCI-H446)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

CLPUB00716
Hui-Jun Zhang, Yun-Li Yan, Li-Fen Zheng, Ping Wan;
Establishment and characterization of an etoposide-resistant human small cell lung cancer cell line H446/VP.
Zhong Liu 24:233-236(2004)

PubMed=21163134; DOI=10.3760/cma.j.issn.0366-6999.2010.22.024
Yan-Ling Wang, Yun-Li Yan, Na-Jing Zhou, Shuo Han, Jun-Xia Zhao, Cui-Li Cao, Yu-Hong Lu;
Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP.
Chin. Med. J. 123:3299-3303(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1MD
Encyclopedic resources Wikidata; Q114311556
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7