Cellosaurus cell line DOS16 (CVCL

Cellosaurus DOS16 (CVCL_C1HQ)

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Cell line name

DOS16

Synonyms

DOS-16; LMS-LFS

Accession

CVCL_C1HQ

Resource Identification Initiative

To cite this cell line use: DOS16 (RRID:CVCL_C1HQ)

Comments

Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Doubling time: 44 hours (DOI=10.26190/unsworks/20387).
Karyotypic information: Near triploid karyotype (DOI=10.26190/unsworks/20387).
Miscellaneous: STR profile from personal communication of MacKenzie, Karen L.
Derived from site: Metastatic; Retroperitoneal space; UBERON=UBERON_0003693.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Heterozygous (DOI=10.26190/unsworks/20387).

Disease

Li-Fraumeni syndrome (NCIt: C3476)
Retroperitoneal leiomyosarcoma (NCIt: C27904)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Leiomyosarcoma (ORDO: Orphanet_64720)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

37Y

Category

Cancer cell line

STR profile

Source(s): Direct_author_submission

Markers:

Amelogenin	X
CSF1PO	10,13
D3S1358	15,16
D5S818	12,13
D7S820	9,11
D8S1179	8,14
D13S317	11,12
D16S539	12
D18S51	14
D21S11	30,32.2
FGA	21,23
Penta D	11
Penta E	7,13
TH01	7,9.3
TPOX	8
vWA	16,18

Publications

CLPUB00712
Jeremy David Henson;
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006); University of Sydney; Sydney; Australia

DOI=10.26190/unsworks/20387
Romi Das Gupta;
Gene profiling in soft tissue sarcoma: predictive value of EGFR in sarcoma tumour progression and survival.
Thesis PhD (2007); University of New South Wales; Sydney; Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C1HQ

Encyclopedic resources

Wikidata; Q114311323

Entry history

Entry creation

22-Sep-2022

Last entry update

19-Dec-2024

Version number