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Cellosaurus DOS16 (CVCL_C1HQ)

[Text version]
Cell line name DOS16
Synonyms DOS-16; LMS-LFS
Accession CVCL_C1HQ
Resource Identification Initiative To cite this cell line use: DOS16 (RRID:CVCL_C1HQ)
Comments Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656).
Doubling time: 44 hours (DOI=10.26190/unsworks/20387).
Karyotypic information: Near triploid karyotype (DOI=10.26190/unsworks/20387).
Miscellaneous: STR profile from personal communication of MacKenzie K.
Derived from site: Metastatic; Retroperitoneal space; UBERON=UBERON_0003693.
Sequence variations
Disease Li-Fraumeni syndrome (NCIt: C3476)
Retroperitoneal leiomyosarcoma (NCIt: C27904)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Leiomyosarcoma (ORDO: Orphanet_64720)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): Direct_author_submission

Markers:
AmelogeninX
CSF1PO10,13
D3S135815,16
D5S81812,13
D7S8209,11
D8S11798,14
D13S31711,12
D16S53912
D18S5114
D21S1130,32.2
FGA21,23
Penta D11
Penta E7,13
TH017,9.3
TPOX8
vWA16,18

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Publications

CLPUB00712
Henson J.D.
The role of alternative lengthening of telomeres in human cancer.
Thesis PhD (2006), University of Sydney, Australia

DOI=10.26190/unsworks/20387
Das Gupta R.
Gene profiling in soft tissue sarcoma: predictive value of EGFR in sarcoma tumour progression and survival.
Thesis PhD (2007), University of New South Wales, Australia

PubMed=19935656; DOI=10.1038/nbt.1587
Henson J.D., Cao Y., Huschtscha L.I., Chang A.C.-M., Au A.Y.M., Pickett H.A., Reddel R.R.
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1HQ
Encyclopedic resources Wikidata; Q114311323
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5