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Cellosaurus CS-THL1 (CVCL_C1GK)

[Text version]
Cell line name CS-THL1
Synonyms Cedars Sinai-Triple-Hit Lymphoma 1
Accession CVCL_C1GK
Resource Identification Initiative To cite this cell line use: CS-THL1 (RRID:CVCL_C1GK)
Comments Characteristics: Has chromosomal translocation of the MYC, BCL2 and BCL6 genes.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Disease High grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements (NCIt: C131913)
High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement (ORDO: Orphanet_480541)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=25916698; DOI=10.1016/j.leukres.2015.04.003
Cinar M., Rosenfelt F., Rokhsar S., Lopategui J., Pillai R.K., Cervania M., Pao A., Cinar B., Alkan S.
Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas.
Leuk. Res. 39:730-738(2015)

PubMed=35687491; DOI=10.1182/bloodadvances.2021006709; PMCID=PMC9631616
Zhang J.-B., Wang T.-T., Shetty K., Alkan S., Xu S.-L., Gong Q., Liu X.-X., Li Y.-P., Hu Z.-S., Huang W.-D., Wendel H.-G., Herrera A.F., Pillai R.K., Song J.Y., Chan W.-C.
Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines.
Blood Adv. 6:5067-5071(2022)

Cross-references
Encyclopedic resources Wikidata; Q114311286
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number5