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Cellosaurus CS-THL1 (CVCL_C1GK)

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Cell line name CS-THL1
Synonyms Cedars Sinai-Triple-Hit Lymphoma 1
Accession CVCL_C1GK
Resource Identification Initiative To cite this cell line use: CS-THL1 (RRID:CVCL_C1GK)
Comments Characteristics: Has chromosomal translocation of the MYC, BCL2 and BCL6 genes.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Disease High grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements (NCIt: C131913)
High grade B-cell lymphoma with MYC and/or BCL2 and/or BCL6 rearrangement (ORDO: Orphanet_480541)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 85Y
Category Cancer cell line
Publications

PubMed=25916698; DOI=10.1016/j.leukres.2015.04.003
Munevver Cinar, Fred Rosenfelt, Sepehr Rokhsar, Jean Lopategui, Raju K. Pillai, Melissa Cervania, Andy Pao, Bekir Cinar, Serhan Alkan;
Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas.
Leuk. Res. 39:730-738(2015)

PubMed=35687491; DOI=10.1182/bloodadvances.2021006709; PMCID=PMC9631616
Ji-Bin Zhang, Ting-Ting Wang, Kunal Shetty, Serhan Alkan, Sen-Lin Xu, Qiang Gong, Xu-Xiang Liu, Yu-Ping Li, Zun-Song Hu, Wen-Dong Huang, Hans-Guido Wendel ...Show all 15 authors... , Alex F. Herrera, Raju K. Pillai, Joo Y. Song, Wing-Chung Chan; Show fewer authors
Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines.
Blood Adv. 6:5067-5071(2022)

Cross-references
Encyclopedic resources Wikidata; Q114311286
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number5