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Cellosaurus U251-NF-kappaB-GFP-Luc-A1 (CVCL_C1CP)

[Text version]
Cell line name U251-NF-kappaB-GFP-Luc-A1
Accession CVCL_C1CP
Resource Identification Initiative To cite this cell line use: U251-NF-kappaB-GFP-Luc-A1 (RRID:CVCL_C1CP)
Comments Population: Caucasian.
Characteristics: Transduced with a construct containing a fused GFP-Luc protein expressed under the control of a promoter containing multiple copies of the NF-kappaB response element.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0021 (U-251MG)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line

PubMed=28790798; DOI=10.1155/2017/6209865
Zeuner M.-T., Vallance T., Vaiyapuri S., Cottrell G.S., Widera D.
Development and characterisation of a novel NF-kappaB reporter cell line for investigation of neuroinflammation.
Mediators Inflamm. 2017:6209865.1-6209865.10(2017)

Cell line databases/resources cancercelllines; CVCL_C1CP
Encyclopedic resources Wikidata; Q114313145
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5