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Cellosaurus MCF10A_MLH1_5 (CVCL_C1A1)

[Text version]
Cell line name MCF10A_MLH1_5
Accession CVCL_C1A1
Resource Identification Initiative To cite this cell line use: MCF10A_MLH1_5 (RRID:CVCL_C1A1)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; 7127; MLH1.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437
Cook A.L., Wyhs N., Sur S., Ptak B., Popoli M., Dobbyn L., Papadopoulos T., Bettegowda C., Papadopoulos N., Vogelstein B., Zhou S., Kinzler K.W.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
IScience 25:104437.1-104437.14(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312244
Sequence databases EGA; EGAD00001008559
Entry history
Entry creation22-Sep-2022
Last entry update29-Jun-2023
Version number4