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Cellosaurus MCF10A_MLH1_5 (CVCL_C1A1)

[Text version]
Cell line name MCF10A_MLH1_5
Accession CVCL_C1A1
Resource Identification Initiative To cite this cell line use: MCF10A_MLH1_5 (RRID:CVCL_C1A1)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:7127; MLH1.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0598 (MCF-10A)
Sex of cell Female
Age at sampling 36Y
Category Spontaneously immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437; PMCID=PMC9184558
Cook A.L., Wyhs N., Sur S., Ptak B., Popoli M., Dobbyn L., Papadopoulos T., Bettegowda C., Papadopoulos N., Vogelstein B., Zhou S.-B., Kinzler K.W.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
iScience 25:104437.1-104437.13(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312244
Sequence databases EGA; EGAD00001008559
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7