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Cellosaurus PCI-04B (CVCL_C171)

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Cell line name PCI-04B
Synonyms PCI-4B; PCI4B; PCI-4M; PCI-4.2
Accession CVCL_C171
Resource Identification Initiative To cite this cell line use: PCI-04B (RRID:CVCL_C171)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.38
Native American0
East Asian, North1.29
East Asian, South0
South Asian0
European, North61.21
European, South37.12
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C170 ! PCI-04A
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298531

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S82012,13
D13S31710,11
D16S53912,13
TH016,7
TPOX9
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=2766286
Dae Seog Heo, Carl Henry Snyderman, Susanne M. Gollin, Shao-Ming Pan, Emily Walker, Ranjan Deka, E. Leon Barnes, Jonas T. Johnson, Ronald Bruce Herberman, Theresa L. Whiteside;
Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines.
Cancer Res. 49:5167-5175(1989)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8084624; DOI=10.1177/01945998941113P105
Carl Henry Snyderman, Ivica Klapan, Michelle Milanovich, Dae Seog Heo, Robin Wagner, Donald R. Schwartz, Jonas T. Johnson, Theresa L. Whiteside;
Comparison of in vivo and in vitro prostaglandin E2 production by squamous cell carcinoma of the head and neck.
Otolaryngol. Head Neck Surg. 111:189-196(1994)

PubMed=14996750; DOI=10.1158/0008-5472.CAN-03-2968
Jun Wang, Li-Qiang Xi, Jennifer L. Hunt, William Gooding, Theresa L. Whiteside, Zhuo Chen, Tony E. Godfrey, Robert Louis Ferris;
Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype.
Cancer Res. 64:1861-1866(2004)

PubMed=17312569; DOI=10.1002/hed.20478
Charles J. Lin, Jennifer Rubin Grandis, Thomas E. Carey, Susanne M. Gollin, Theresa L. Whiteside, Wayne M. Koch, Robert Louis Ferris, Stephen Y. Lai;
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C171
Cell_Model_Passport; SIDM00043
Cosmic-CLP; 1298531
DepMap; ACH-002297
CRISP screens repositories BioGRID_ORCS_Cell_line; 989
Chemistry resources GDSC; 1298531
PharmacoDB; PCI4B_1253_2019
Encyclopedic resources Wikidata; Q54938650
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827146
GEO; GSM1670344
Polymorphism and mutation databases Progenetix; CVCL_C171
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number30