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Cellosaurus BL-37 (CVCL_C147)

[Text version]
Cell line name BL-37
Synonyms BL37; BL 37; BL 037; IARC/BL37; IARC/BL 37; IARC-BL37; IARC BL37; IARC BL 37
Accession CVCL_C147
Resource Identification Initiative To cite this cell line use: BL-37 (RRID:CVCL_C147)
Comments From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Caucasian; French.
Virology: Contains a complete EBV genome (strain BL37) which has been sequenced (PubMed=25787276).
Doubling time: ~50-60 hours (DSMZ=ACC-918).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_VQ32 ! BL-39
CVCL_IV05 ! IARC-176A
CVCL_A2XI ! IARC-176B
CVCL_VQ22 ! IARC-303A
CVCL_A2XH ! IARC-303B
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-918

Markers:
AmelogeninX,Y
CSF1PO12,13
D2S133819,24
D3S135814,15
D5S81811
D7S82010,12
D8S117913,14
D13S31711,12
D16S53911,12
D18S519,18
D19S43314,15
D21S1130,32.2
FGA21,25
Penta D9,12
Penta E6,15
TH018,9
TPOX11
vWA17

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Publications

PubMed=6087353; DOI=10.1073/pnas.81.15.4930
Bornkamm G.-W., von Knebel-Doeberitz M., Lenoir G.M.
No evidence for differences in the Epstein-Barr virus genome carried in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from the same patients.
Proc. Natl. Acad. Sci. U.S.A. 81:4930-4934(1984)

PubMed=6090749; DOI=10.1093/jnci/73.4.835
Philip I., Philip T., Favrot M.-C., Vuillaume M., Fontaniere B., Chamard D., Lenoir G.M.
Establishment of lymphomatous cell lines from bone marrow samples from patients with Burkitt's lymphoma.
J. Natl. Cancer Inst. 73:835-840(1984)

PubMed=6422306; DOI=10.1038/307752a0
Hollis G.F., Mitchell K.F., Battey J., Potter H., Taub R., Lenoir G.M., Leder P.
A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma.
Nature 307:752-755(1984)

PubMed=2985508; DOI=10.1002/ijc.2910350404
Rowe M., Rooney C.M., Rickinson A.B., Lenoir G.M., Rupani H., Moss D.J., Stein H., Epstein M.A.
Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma.
Int. J. Cancer 35:435-441(1985)

PubMed=3934070
Lenoir G.M., Vuillaume M., Bonnardel C.
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=3027441; DOI=10.1093/jnci/78.2.235
Cohen J.H.M., Revillard J.-P., Magaud J.-P., Lenoir G.M., Vuillaume M., Manel A.-M., Vincent C., Bryon P.-A.
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
J. Natl. Cancer Inst. 78:235-242(1987)

PubMed=3035497; DOI=10.1093/nar/15.11.4553
Szajnert M.-F., Saule S., Bornkamm G.-W., Wajcman H., Lenoir G.M., Kaplan J.-C.
Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.
Nucleic Acids Res. 15:4553-4565(1987)

PubMed=2898508; DOI=10.1084/jem.167.6.1811
Gregory C.D., Murray R.J., Edwards C.F., Rickinson A.B.
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
J. Exp. Med. 167:1811-1824(1988)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=8108117
Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene 9:759-763(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=11793449; DOI=10.1002/gcc.10022
Sobol H., Benziane A., Kerangueven F., Yin L., Noguchi T., Pauly S., Eisinger F., Longy M., Romeo G., Lenoir G.M., Birnbaum D.
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Genes Chromosomes Cancer 33:217-224(2002)

PubMed=25787276; DOI=10.1128/JVI.03614-14
Palser A.L., Grayson N.E., White R.E., Corton C., Correia S., Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G., Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

Cross-references
Cell line collections (Providers) DSMZ; ACC-918
Cell line databases/resources cancercelllines; CVCL_C147
DSMZCellDive; ACC-918
Encyclopedic resources Wikidata; Q54797148
Polymorphism and mutation databases Cosmic; 931119
Cosmic; 2804866
IARC_TP53; 136
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number21