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Cellosaurus BL-30 (CVCL_C142)

[Text version]
Cell line name BL-30
Synonyms BL30; BL 30; BL 030; IARC/BL30; IARC/BL 30; IARC-BL30; IARC BL30; IARC BL 30
Accession CVCL_C142
Resource Identification Initiative To cite this cell line use: BL-30 (RRID:CVCL_C142)
Comments From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Caucasian.
Virology: EBV-negative.
Doubling time: 15-24 hours (Note=Depending on cell density) (DSMZ=ACC-916).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,11:01
HLA-BB*08:01,39:01
HLA-CC*02:02,07:01
Class II
HLA-DQDQA1*01:03,05:01
DQB1*02:01,06:03
HLA-DRDRB1*03:01,13:01
Disease Burkitt lymphoma (NCIt: C2912)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M567 ! BL-28
CVCL_C144 ! BL-32
CVCL_IV21 ! IARC-139
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-916

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133819,24
D3S135817,18
D5S81811
D7S8208,12
D8S117910,13
D13S31711,12
D16S53911,12
D18S5112,13
D19S43313,14
D21S1130,31.2
FGA23,25
Penta D8,9
Penta E12,16
TH016,7
TPOX8,11
vWA14,15

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Publications

PubMed=6090749; DOI=10.1093/jnci/73.4.835
Irene Philip, Thierry Philip, Marie-Christine Favrot, Michele Vuillaume, Bernard Fontaniere, Didier Chamard, Gilbert Marcel Lenoir;
Establishment of lymphomatous cell lines from bone marrow samples from patients with Burkitt's lymphoma.
J. Natl. Cancer Inst. 73:835-840(1984)

PubMed=6231253; DOI=10.1002/ijc.2910330407
Barbro Ehlin-Henriksson, George Klein;
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Int. J. Cancer 33:459-463(1984)

PubMed=3934070
Gilbert Marcel Lenoir, Michele Vuillaume, Colette Bonnardel;
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=2825176; DOI=10.1073/pnas.84.22.8060; PMCID=PMC299477
Alain Calender, Marc Billaud, Jean-Pierre Aubry, Jacques Banchereau, Michele Vuillaume, Gilbert Marcel Lenoir;
Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.
Proc. Natl. Acad. Sci. U.S.A. 84:8060-8064(1987)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998
Paul J. Farrell, Gordon J. Allan, Frances Shanahan, Karen Heather Vousden, Tim Crook;
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781
Gianluca Gaidano, Robert S. Hauptschein, Nasser Z. Parsa, Kenneth Offit, Pulivarthi H. Rao, Gilbert Marcel Lenoir, Daniel M. Knowles, Raju S.K. Chaganti, Riccardo Dalla-Favera;
Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.
Blood 80:1781-1787(1992)

PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Vinay K. Jain, Jean-Gabriel Judde, Edward E. Max, Ian Trevor Magrath;
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=8896424; DOI=10.1182/blood.V88.9.3562.bloodjournal8893562
Caroline J. Chapman, Jo X. Zhou, Christopher D. Gregory, Alan Bernard Rickinson, Freda K. Stevenson;
VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.
Blood 88:3562-3568(1996)

PubMed=9973220
Marina I. Gutierrez, Barry W. Cherney, Azhar Hussain, Howard S. Mostowski, Giovanna Tosato, Ian Trevor Magrath, Kishor G. Bhatia;
Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.
Cancer Res. 59:696-703(1999)

PubMed=11793449; DOI=10.1002/gcc.10022
Hagay Sobol, Athmane Benziane, Fabienne Kerangueven, Luo Yin, Tetsuro Noguchi, Suzanne Pauly, Francois Eisinger, Michel Longy, Giovanni Romeo, Gilbert Marcel Lenoir, Daniel Birnbaum;
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Genes Chromosomes Cancer 33:217-224(2002)

PubMed=22885699; DOI=10.1038/nature11378; PMCID=PMC3609867
Roland Schmitz, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wen-Ming Xiao, Mei-Li Zhang, George Wright, Arthur L. Shaffer 3rd, Daniel James Hodson, Eric Buras, Xue-Lu Liu ...Show all 42 authors... , John I. Powell, Yan-Dan Yang, Wei-Hong Xu, Hong Zhao, Holger Kohlhammer, Andreas Rosenwald, Philip M. Kluin, Hans-Konrad Muller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine Sarkin Jaffe, Jan Delabie, Erlend Bremertun Smeland, Martin David Ogwang, Steven J. Reynolds, Richard I. Fisher, Rita Merle Braziel, Raymond Roy Tubbs, James R. Cook, Dennis D. Weisenburger, Wing-Chung Chan, Stefania Pittaluga, Wesley Wilson, Thomas Alexander Waldmann, Martin Rowe, Sam M. Mbulaiteye, Alan Bernard Rickinson, Louis Michael Staudt; Show fewer authors
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Nature 490:116-120(2012)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-916
Cell line databases/resources cancercelllines; CVCL_C142
DSMZCellDive; ACC-916
Encyclopedic resources Wikidata; Q54797136
Polymorphism and mutation databases Cosmic; 2814532
IARC_TP53; 701
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number23