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Cellosaurus SP-53 (CVCL_C122)

[Text version]
Cell line name SP-53
Synonyms SP53; DBsp53; DB-sp53
Accession CVCL_C122
Resource Identification Initiative To cite this cell line use: SP-53 (RRID:CVCL_C122)
Comments Population: Japanese.
Doubling time: 57 hours (PubMed=11061568).
Omics: Variations; Array-based CGH.
Miscellaneous: HLA typing from personal communication of Pellat-Deceunynck, Catherine.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: Direct_author_submission
Class I
HLA-AA*02,24
HLA-BB*40,56
HLA-CC*03,04
Disease Mantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UW48 (SP-53 EBV-infected)
Originate from same individual CVCL_D022 ! SP-49
CVCL_C121 ! SP-50B
CVCL_M655 ! SP-52EB
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=2548699; DOI=10.1002/1097-0142(19890915)64:6<1248::AID-CNCR2820640614>3.0.CO;2-5
Masanori Daibata, Ichiro Kubonishi, Taisuke Eguchi, Shoki Yano, Yuji Ohtsuki, Isao Miyoshi;
The establishment of Epstein-Barr virus nuclear antigen-positive (SP-50B) and Epstein-Barr virus nuclear antigen-negative (SP-53) cell lines with t(11;14)(q13;q32) chromosome abnormality from an intermediate lymphocytic lymphoma.
Cancer 64:1248-1253(1989)

PubMed=8971032; DOI=10.1128/JVI.70.12.9003-9007.1996; PMCID=PMC191000
Masanori Daibata, Ichiro Kubonishi, Isao Miyoshi;
Differential tumorigenicity between Epstein-Barr virus genome-positive and genome-negative cell lines with t(11;14)(q13;q32) derived from mantle cell lymphoma.
J. Virol. 70:9003-9007(1996)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=11061568; DOI=10.18926/AMO/32293
Zhai-Shun Jin, Norihiro Teramoto, Tadashi Yoshino, Kenzo Takada, Takashi Oka, Kazuhiko Hayashi, Tadaatsu Akagi;
Characterization of Epstein-Barr virus-infected mantle cell lymphoma lines.
Acta Med. Okayama 54:193-200(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12683869; DOI=10.5858/2003-127-0424-COMCLC
Hesham M. Amin, Timothy J. McDonnell, L. Jeffrey Medeiros, Georgios Z. Rassidakis, Vasiliki Leventaki, Sean L. O'Connor, Michael J. Keating, Raymond Lai;
Characterization of 4 mantle cell lymphoma cell lines. Establishment of an in vitro study model.
Arch. Pathol. Lab. Med. 127:424-431(2003)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=26194763; DOI=10.1182/blood-2015-01-624585; PMCID=PMC4582332
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, De-Kuang Zhao, Xiao-Yu Jiang, Elif Isik, Anthony George Letai, Izidore S. Lossos;
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Blood 126:1555-1564(2015)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Lan V. Pham, Sheng-Jian Huang, Hui Zhang, Jun Zhang, Taylor Bell, Shou-Hao Zhou, Elizabeth Pogue, Zhi-Yong Ding, Laura Lam, Jason Westin, R. Eric Davis ...Show all 17 authors... , Ken H. Young, L. Jeffrey Medeiros, Richard Joseph Ford Jr., Krystle Nomie, Leo Zhang, Michael Wang; Show fewer authors
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C122
Encyclopedic resources Wikidata; Q54955389
Gene expression databases GEO; GSM119539
Polymorphism and mutation databases Cosmic; 1070710
Cosmic; 2296998
Progenetix; CVCL_C122
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number21