Cellosaurus cell line ImGNC (CVCL

Cross-references
Cell line name	ImGNC
Synonyms	Immortalized Giant Nevi Cells
Accession	CVCL_C0WR
Resource Identification Initiative	To cite this cell line use: ImGNC (RRID:CVCL_C0WR)
Comments	Population: Chinese. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Arm, skin, dermis; UBERON=UBERON_0002427+UBERON_0002067.
Sequence variations	Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=35218152).
Disease	Giant congenital nevus (NCIt: C4234)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	7Y
Category	Transformed cell line
Publications	PubMed=35218152; DOI=10.1111/pcmr.13033 Qing-Xiong Yu, Rehanguli Aimaier, Man-Hon Chung, Xi-Wei Cui, Yue-Hua Li, Zhi-Chao Wang, Qing-Feng Li; Establishment and characterization of an immortalized human giant congenital melanocytic nevi cell line. Pigment Cell Melanoma Res. 35:356-368(2022)
Encyclopedic resources	Wikidata; Q114311737
Entry history
Entry creation	22-Sep-2022
Last entry update	14-Aug-2025
Version number	8