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Cellosaurus LNCaP-PDR2 (CVCL_C0RS)

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Cell line name LNCaP-PDR2
Synonyms LNCaP PDR2; LN-PDR2
Accession CVCL_C0RS
Resource Identification Initiative To cite this cell line use: LNCaP-PDR2 (RRID:CVCL_C0RS)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_85993; Palbociclib (Ibrance).
Omics: Proteomics; PTM; Phosphorylation; Quantitative.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187
Renee de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel-Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, Edward Starr Hazard ...Show all 17 authors... , Gary Hardiman, Maha H. Hussain, John Alan Diehl, Justin M. Drake, William Kevin Kelly, Karen E. Knudsen; Show fewer authors
MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer.
Clin. Cancer Res. 24:4201-4214(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0RS
Encyclopedic resources Wikidata; Q112930020
Gene expression databases GEO; GSM2650011
GEO; GSM2650012
GEO; GSM2650013
GEO; GSM2650014
GEO; GSM2650015
GEO; GSM2650016
Proteomic databases PRIDE; PXD006561
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7